Sulfa allergy

Sulfa
allergy
sulfa allergy" is a term used to describe [ندعوك للتسجيل في المنتدى أو التعريف بنفسك لمعاينة هذا الرابط] to
sulfonamides, a group of drugs that includes those with and without antibiotic
characteristics.

The antibiotic sulfonamides are different structurally from the non-antibiotic
sulfonamides, and appear to be much more likely to result in [ندعوك للتسجيل في المنتدى أو التعريف بنفسك لمعاينة هذا الرابط].
Many of the sulfa non-antibiotics, therefore, do not cause problems in people
with sulfa antibiotic allergy.

Symptoms in
sulfa allergy
1. Skin reactions: ranging from various benign rashes
to life-threatening Stevens-Johnson syndrome and toxic
epidermal necrolysis. [ندعوك للتسجيل في المنتدى أو التعريف بنفسك لمعاينة هذا الرابط] and increased sensitivity
to sunlight (photosensitivity).
2. Liver and kidney injury: People with sulfa allergy may also develop a
type of [ندعوك للتسجيل في المنتدى أو التعريف بنفسك لمعاينة هذا الرابط], and kidney
failure, as a result of sulfa medications.
3. Lung reactions: Sulfa allergy can also affect the lung, with
pneumonia-like reactions, worsening [ندعوك للتسجيل في المنتدى أو التعريف بنفسك لمعاينة هذا الرابط] and [ندعوك للتسجيل في المنتدى أو التعريف بنفسك لمعاينة هذا الرابط] occurring.
4. Blood reactions: Sulfa allergy can also affect various blood cells,
resulting in decreased white blood cells, red blood cells, and platelets,
through an immunologic-mediated manner.


In some cases, in which a sulfa medication is needed to treat certain
infections, a person can be desensitized to the medication. This is done by
initially giving very small amounts of the medication, with increasing amounts
given over a period of time so that the medication is tolerated. The
sulfonamide medication can also be cautiously continued despite the adverse
side effect.

What
medications should sulfa-allergic patients avoid
1.
Sulfa antibiotics: sulfonamide antibiotics should be
avoided. These include trimethoprim-sulfamethoxazole, sulfadizine, sulfisoxazole,
and dapsone. Topical sulfa antibiotics, such as sulfacetamide eye
drops/shampoos/creams, silver sulfadiazine cream, and sulfanilamide vaginal
preparations.
2. Diuretics: The risk for sulfa-containing diuretic medications causing
reactions in sulfa-allergic patients is low. Many diuretic medications, such as
[ندعوك للتسجيل في المنتدى أو التعريف بنفسك لمعاينة هذا الرابط]
and [ندعوك للتسجيل في المنتدى أو التعريف بنفسك لمعاينة هذا الرابط] are
sulfa-based, while [ندعوك للتسجيل في المنتدى أو التعريف بنفسك لمعاينة هذا الرابط]
is not. While there is no proof that people with an allergy to sulfa-based
antibiotics will also react to sulfa-based non-antibiotics, it is recommended
that a sulfa-allergic person take the first dose of a sulfa-based diuretic
under direct medical supervision.
3. Sulfonylureas: (such as chloropropamide, glyburide, and glipizide),
are structurally similar to sulfonamides. While there are a few reports of
these medications causing problems in sulfa-allergic patients, these
medications are generally tolerated.
4. Celecoxib: sulfa-allergic patients should avoid this medication.
5. Sulfasalazine: Sulfasalazine is a sulfonamide that is related to
aspirin, and is used for [ندعوك للتسجيل في المنتدى أو التعريف بنفسك لمعاينة هذا الرابط]
and [ندعوك للتسجيل في المنتدى أو التعريف بنفسك لمعاينة هذا الرابط].
This medication should not be used in people with sulfa allergy.
6. Sumatriptan: used for the treatment of [ندعوك للتسجيل في المنتدى أو التعريف بنفسك لمعاينة هذا الرابط], is related structurally to
sulfonamides, although there is no evidence that people with sulfa allergy are
at increased risk for reactions from this medication.
7. Zonisamide: Zonisamide is a sulfonamide medication used for the
treatment of [ندعوك للتسجيل في المنتدى أو التعريف بنفسك لمعاينة هذا الرابط]. It has been
associated with severe skin reactions, those typically seen with sulfa
reactions. This medication should not be used in sulfa-allergic patients.